Get this from a library epidemiology of chronic respiratory disease a literature review prepared for office of research and development environmental protection agency i t t higgins national environmental research center research triangle park nc human studies laboratory. epa 650 1 74 007 epidemiology of chronic respiratory disease a literature review by dr itt higgins department of epidemiology school of public health university of michigan ann arbor michigan 48104 contract no ph 86 68 142 program element no nc 27711 prepared for office of research and development environmental protection . Introduction chronic obstructive pulmonary disease copd is a chronic respiratory disease characterized by a decline in lung function over time and accompanied by respiratory symptoms primarily dyspnea cough and sputum production1 consequently copd is associated with a significant economic burden including hospitalization work absence and disability1 current data suggest that copd . Epidemiology of chronic obstructive pulmonary disease a literature review the aim of this study is to quantify the burden of chronic obstructive pulmonary disease copd incidence . Introduction chronic obstructive pulmonary disease copd is one of the leading causes of morbidity and mortality worldwide especially in the industrialized and the developing countries1 6 copd is a progressive pulmonary disease that may have a profound impact on the general health status and quality of life7 9 these factors motivate extensive research studies in this disease area
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